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pentobarbital will decrease the level or impact of etravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.pentobarbital raises toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers may well raise the metabolism of ifosfamide to its active alkyl